Question: What Do High Protein Levels In Spinal Fluid Mean?

How do you read a CSF report?

Interpretation of CSF results from lumbar puncture (LP)Appearance: Clear.Opening pressure: 10-20 cmCSF.WBC count: 0-5 cells/µL.

< 2 polymorphonucleocytes [PMN]) ...

Glucose level: >60% of serum glucose.Protein level: < 45 mg/dL.Consider additional tests: CSF culture, others depending on clinical findings..

What is considered high protein in CSF?

EVALUATION. Spinal fluid protein concentration is usually moderately elevated, with concentrations in the 150 to 300 mg/100 mL range.

What is a normal CSF protein level?

The normal protein range varies from lab to lab, but is typically about 15 to 60 milligrams per deciliter (mg/dL) or 0.15 to 0.6 milligrams per milliliter (mg/mL).

Why is CSF protein high in Guillain Barre?

Elevated CSF protein concentration in GBS has been mainly associated with increased permeability of the blood-CSF barrier. In our series, 18 (51.4%) patients showed albuminocytological dissociation (raised protein concentration without pleocytosis) on CSF examination.

Why would a neurologist order a spinal tap?

A lumbar puncture can help diagnose serious infections, such as meningitis; other disorders of the central nervous system, such as Guillain-Barre syndrome and multiple sclerosis; or cancers of the brain or spinal cord.

Does high protein in CSF mean MS?

Cerebral Spinal Fluid Studies Oligoclonal Immunoglobulin Bands can be identified in the CSF of MS patients via electrophoresis. The overall protein level is also slightly elevated – up to 0.1 g/L. Protein level can be higher if the patient is going through a marked relapse (i.e.,. severe optic neuritis).

Why does bacterial meningitis cause increased protein levels in the CSF?

CSF protein Bacterial meningitis leads to a more permeable blood brain barrier (due to increased inflammation). Protein leaks into the subarachnoid space from the blood, resulting in markedly increased CSF protein levels.

What does high glucose in spinal fluid mean?

High CSF glucose levels In addition, damage to small blood vessels during lumbar puncture (traumatic tap) can lead to an increased CSF glucose since the blood that enters the collected CSF sample contains higher levels of glucose. CSF glucose levels do not generally exceed 16.7 mmol/L (300 mg/dL).

Why does glucose decrease with meningitis?

The reason for the reduced glucose levels associated with bacterial meningitis was believed to be the need for glucose as fuel by infiltrating immune cells in response to infection. However, the possibility that the bacteria itself could manipulate glucose concentrations in the brain had not been explored before now.